Role of a non‐CFTR chloride channel in intestinal epithelial chloride secretion
نویسندگان
چکیده
منابع مشابه
Effects of quercetin on epithelial chloride secretion.
The effect of the flavonoid quercetin on epithelial chloride secretion has been studied in vitro. These studies were performed using monolayers of the human colonic epithelial cell line T84, mounted in modified Ussing chambers. Chloride secretion was assessed as changes in short circuit current (I(SC)) both in basal conditions as well as in response to different secretagogues: carbachol (100 mi...
متن کاملPhysiology of epithelial chloride and fluid secretion.
Epithelial salt and water secretion serves a variety of functions in different organ systems, such as the airways, intestines, pancreas, and salivary glands. In cystic fibrosis (CF), the volume and/or composition of secreted luminal fluids are compromised owing to mutations in the gene encoding CFTR, the apical membrane anion channel that is responsible for salt secretion in response to cAMP/PK...
متن کاملClC-2 and intestinal chloride secretion.
TO THE EDITOR: Beyder and Farrugia (1) state in their recently published review that lubiprostone is an opener of ClC-2 chloride channels and that through that action it can ameliorate constipation, implying that ClC-2 would mediate chloride and therefore fluid secretion. Support for this claim is provided through citation of a previous review (8). Nevertheless, both reviews overlook evidence c...
متن کاملEpithelial Chloride Channel Development of lnhibitory Ligands
I N T R O D U C T I O N Chloride channels are present in the plasma membranes o f epithelia (Frizzell et al., 1981), nerve (Hamill et al., 1983), and muscle (Blatz and Magleby, 1985), as well as in intraceilular membranes such as Golgi apparatus (Glickman et al., Address reprint requests to Dr. Qais AI-Awqati, Depts. of Medicine and Physiology, College of Physicians and Surgeons, Columbia Unive...
متن کاملEpithelial chloride channel. Development of inhibitory ligands
Chloride channels are present in the majority of epithelial cells, where they mediate absorption or secretion of NaCl. Although the absorptive and secretory channels are well characterized in terms of their electrophysiological behavior, there is a lack of pharmacological ligands that can aid us in further functional and eventually molecular characterization. To obtain such ligands, we prepared...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.1014.1